His most important work is a massive Fresco painted around 1482 entitled The Delivery of the Keys, depicts a standing Christ and his apostles delivering a massive key to a kneeling St. Peter. The nearly two-dozen life-size figures in the painting are arrayed across th lower picture plane in the foreground while a second group of some 50 or more middle-ground figures mindle just over their heads deep within an open space, perfectly proportioned to those in the foreground.
In the background, perfectly rendered in amazing detail is a domed, octagonal church flanked by two Roman archs of the triumphant variety, all drawn in perfect, one-point perspective. The painting is a tour-de-force of early Renaissance painting. In its time, it was heralded as a masterpiec. Yet, Perugino is todayis largely forgotten, and the painting, though prominantly displayed, is largely ignored. Why? Well, it has suffered the misfortune of having been upstaged by an even more important work of Renaissance art. Perugino's The Delivery of the Keys graces the left wall, some twenty feet above the floor, of the Sistine Chapel.